Ocular Surface Ion Transport and Dry Eye Disease

Abstract Purpose of Review To review the role ocular surface epithelial (corneal and conjunctival) ion transporters in pathogenesis treatment dry eye disease (DED). Recent Findings Currently, anti-inflammatory agents are mainstay DED treatment, though there several development that target transport proteins on surface, acting by pro-secretory or anti-absorptive mechanisms to increase tear fluid film volume. Activation inhibition selected can alter osmolality, driving water onto via osmosis. Several have been proposed as potential therapeutic targets for DED, including cystic fibrosis transmembrane conductance regulator (CFTR), calcium-activated chloride channels (CaCCs), sodium channel (ENaC). Summary Ocular cell promising therapies DED.